The Curcuminoids Extract of Curcuma xanthorrhiza RoxB. Loaded Solid Lipid NanoparticlesJournal: International Journal of Science and Research (IJSR) (Vol.3, No. 10)
Publication Date: 2014-10-05
Authors : Laksmi Ambarsari; Waras Nurcholis; Latifah K Darusman; Muslih Abdul Mujib; Rudi Heryanto;
Page : 852-856
Keywords : curcuma xanthorrhiza; solid lipid nanoparticle; curcuminoids; bioavailability; ultra sonication;
Curcuma xanthorrhiza RoxB. is the medicinal plant that widely used in Indonesian traditional herbal medicine (Jamu). The curcuminoids is well known for its pharmacological properties such as antioxidant, anti-inflammatory, and anti-carcinogenic. The curcuminoids is weakly soluble in water that restrict its bioavailability. This problem could be overcome by incorporated curcuminoid into solid lipid nanoparticles (SLN). The purpose of this study was to produce and characterize curcuminoids extract loaded solid lipid nanoparticles (curcuminoids-SLN) from C. xanthorrhiza. The curcuminoids-SLN was prepared using different composition of curcuminoid extract, surfactant and lipid. It was produced by using homogenization-ultra sonication methods. The particle was characterized for its size, properties and entrapment efficiency. Result showed that the best composition for producing curcuminoids-SLN was palmitic acid: curcuminoids: surfactants with weight ratio 1: 0.5: 1.5 with entrapment efficiency 72.98 %. The particle size was 285.576.7 nm. The FTIR spectral data of curcuminoids-SLN was reflection of raw materials spectrum and XRD measurement showed that crystallinity of curcuminoids-SLN in the good agreement with palmitic acid.
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