Hybrid Verrucous Carcinoma - A Case Report

In 1948, Ackerman first coined the term verrucous carcinoma to describe a variant of well-differentiated squamous cell carcinomas of the oral cavity. Similar lesions of the skin, other mucosa or mucocutaneous regions were subsequently reported. To date, verrucous carcinoma has been considered to be a variant of well-differentiated squamous cell carcinoma, which sometimes shows invasive changes but rarely metastasizes. Occasionally foci of invasive squamous cell carcinoma were found in verrucous carcinomas, this entity is called a hybrid verrucous carcinoma. We report a case of this hybrid lesion occurring in the buccal vestibule of a 60 year old male patient. The removed mass shows the typical features of verrucous carcinoma, but focally conventional squamous cell carcinoma area is also noted.