Possibility of Combined Assessment of Biomarkers in Early Parkinsons Disease

Aims& Objectives: There is much evidence that the Parkinsons disease neurodegenerative process begins many years before the onset of motor manifestations. The aim of this study was to investigate the changes in substantia nigra hyperechogenicity and sympathetic skin response in early PD patients. Materials& Methods: 12 patients were studied of which 9 men and 3 women with newly diagnosed with PD, with probable PD, and without clinical evidence of autonomic dysfunctions. The clinical status of patients was evaluated according to the modified scale of Hoehn and Yahr 5 degrees to the second, inclusive. More pronounced changes were seen in 1.5 and 2 on the used scale. Simultaneously, the study of these biomarkers could provide information on morphological and autonomous changes as an opportunity for early assessment of PD. Conclusions: We demonstrated for the first time the combination of biomarkers and methods that could provide information on morphological and autonomous changes for the earlier diagnosis of PD.