Predictive Value of Micronucleus Count in Cervical Smears of Normal, Infective Inflammatory&Intraepithelial Neoplasia Pathology in Perimenopausal Women

Objectives: Consenses guidelines establish that a micronucleus is a small additional nucleus formed due to chromosomal loss or fragmentation. Its a good prognostic indicator for monitoring genetic damage in human population. The objective of this study was to get the predictive value of micronucleus count in cervical smears of normal, infective inflammatory and intraepithelial neoplasia pathology in perimenopausal women and to prove Micronucleus evaluation in routine Pap smears is a very useful biomarker in cervical cancer screening. Material and Method: In this study 90 cases, consisting of 30 normal, 30 trichomonas infective, 30 intraepithelial neoplasia cervical smears of perimenopausal women of age group of (40-45) 2 years in Mahatma Gandhi Medical College and Research Institute, Puducherry from January 2014 - June 2014 were studied for micronucleus count. Only routine papanicolaou-stained cervical smears were used. In each smear, the number of micronucleated cells were counted under high power and expressed as a count per 1, 000 cells. Observation& Results: The predictive value of micronucleus count in squamous intraepithelial lesion greater than infective inflammatory cervical greater than normal cases. The p value is less than 0.01, that is significant. Conclusions: This simple micronucleus test is a powerful biomarker and can be used as a screening procedure in predicting cervical cancer.