Synthesis, Characterization and Antimicrobial Activity of various Chalcone Derivatives

Chalcone are precursor of the natural occurring flavonoids family. Chalcone consists of two aromatic rings linked by three carbon carbonyl system. The chemistry and biological activities of Chalcone has motivate to synthesis Chalcone as a potential compound for antimicrobial activity. In the present work, a series of Chalcone derivatives were synthesized by Claisen-Schmidt Condensation reaction in which various substituted benzaldehyde and acetoaryl were condensed in the presence of aqueous alcoholic alkali solution. The structures of these compounds were confirmed on the basis of the spectral data. The compounds were screened for their antibacterial activity against B. subtilius, S. aureus, E. coli, P. aureoginosa and antifungal activity against A. niger. The results indicate that synthesized compounds have appreciable antibacterial and antifungal activity.