A Concise and Convenient Synthesis of 6-Aryl Angular Phenothiazinones

The synthesis of 6-aryl derivatives of 8-methyl-11-azabenzo [a]phenothiazn-5-one is reported. This was achieved by reacting 2-amino-4-methylpyridine-3-thiol with 2, 3-dichloro-1-4-naphthoquinone under anhydrous basic condition to furnish the parent compound while 6-aryl derivatives were prepared by cross-coupling with arylboronic acids under nickel complex catalysis. The structures assigned to the synthesized compound were supported by spectroscopic and analytical data obtained.