Intracytoplasmic Sperm Injection in Women with Polycystic Ovary Syndrome and Isolated Polycystic Ovary Morphology: A case-Control Study

Objective: To determine the efficacy of intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) in patients with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian morphology (PCOM). Methods: A case-control study was conducted in In Vitro Fertilization center, Maternity Teaching Hospital, Erbil city on total of 190 consecutive infertile women with PCOS, 50 women with isolated PCOM, versus 248 women with normal ovaries. ICSI was conducted for all of them. Results: Despite a significantly lower total follicle-stimulating hormone dose, significantly higher serum estradiol levels were attained in the PCOS and PCOM groups compared with the control group. The PCOS and PCOM groups had significantly more retrieved oocyte-cumulus complexes and metaphase II oocytes compared with the control group. Fertilization rates were similar in all three groups. The mean numbers of grade 1 embryos were significantly more in the PCOS and PCOM groups compared with the controls. The clinical pregnancy rates per cycle were significantly higher in the PCOS (34 %) and PCOM (42 %) groups compared with the control group (25 %), and there were significantly more live births per cycle in the PCOS (28 %) and PCOM (36 %) groups compared with the control group (18.5 %). Conclusions: Patients with PCOS and PCOM respond similarly during all stages of assisted reproduction. The availability of more fertilized oocytes and grade 1 embryos means that patients with PCOS or PCOM have higher clinical pregnancy and live birth rates per cycle compared with normal controls.