Post Operative Radiotherapy in Carcinoma Endometrium - KMIO Experience (A Retrospective Study)

Purpose: To compare the outcomes for postoperative endometrial cancer treated with adjuvant radiotherapy. Methods: 68 patients with stage I to III endometrial cancer treated with Radical hysterectomy + Pelvic lymph node dissection followed by brachytherapy or with a combination of external beam radiotherapy and brachytherapy were retrospectively analysed. Comprehensive surgical staging and pelvic lymph node dissection was done in 94 % of patients. Teletherapy and Brachytherapy was used in 78 % cases, while only brachytherapy was used in the adjuvant setting in 22 %cases. HDR brachytherapy was used in 63 % cases and LDR brachytherapy in 37 % cases. Local control was evaluated in both the brachytherapy groups. Results: For all stages combined, the local control was achieved in 77 % patients in the HDR brachytherapy group and in 88 % of the LDR brachytherapy group. Conclusion: The local control was significantly better in the LDR group when compared to the HDR group. The mean survival and the median survival is better in the HDR group as compared to the LDR group. The subgroup with grade 3 tumors with deep myometrial invasion were benefitted by Teletherapy followed by Brachytherapy. Good local control was seen in patients who received HDR- 6Gy*3 or 7Gy*2 and LDR-30Gy to 0.5cm.