DNA Microarray and its Applications in Disease Diagnosis

With rapid advances in the bioinformatics, computational biology, robotics and fabrication of high quality glass slides, microarray technology is increasingly being used in different laboratories all over the world. A microarray is a collection of microscopic spots arranged in an array on grid- like format and attached to a solid surface or membrane. Each individual spot is present at a precisely defined location on the substrate. In DNA microarray these spots are single stranded DNA fragments. These spots are known as probes. On basis of fluorescenc generated by spots overall gene expression is assessed. gene expression gives a comparative study of healthy and diseased condition. Microarray facilitates us with global analysis of healthy and diseased condition