Study of Effect of Neonatal Septicemia on Renal Function

Aims& Objectives: To study the occurrence of ARF complicating neonatal sepsis and effect of associated contributing factors. Materials and methods: Over a period of 1 year from January to December 2013, out of 449 studied cases with neonatal sepsis, ARF complicated 104 (23.2 %) of neonates. All cases were assessed in detail especially for co-morbidities: nephrotoxic drugs, DIC, shock, maternal drug intake and mechanical ventilation. A full sepsis screen and evaluation of renal functions by estimating the urine output and BUN was carried out for all studied babies. Sepsis was diagnosed on the basis of either a positive sepsis screen or a positive blood culture in symptomatic neonates. ARF was defined as blood urea nitrogen (BUN) greater than45mg/dl on two separate occasions at least 24 hours apart. Oliguria was defined as urine output