Synthesis, Characterization and Evaluation of Antimicrobial Activity of Various Mannich Bases of Isoindoledione Derivatives

Isoindoledione possess a structural featureCO-N (R) -CO-, an imide ring which help them to be biologically active and pharmaceutically useful. Isoindoledione have received attention due to their antibacterial, antifungal, analgesic, antitumor, anxiolytic and anti HIV-1 activities. When Isoindoledione is subjected to Mannich condensation, it yields Mannich bases which may display more biological activities. The increasing popularity of the Mannich reaction has been fueled by the ubiquitous nature of nitrogen containing compounds in drugs and natural products. The aim of the present study is to synthesis Mannich bases of Isoindoledione by Mannich condensation reaction. Isoindoledione reacts with various substituted aromatic aldehydes and substituted amines in presence of mineral acid to give various Mannich bases of Isoindoledione. The synthesized compounds will be characterized by elemental analysis, TLC and structure will confirmed by IR analysis and NMR analysis. Antimicrobial screening of the compounds will be carried out using Serial dilution method.