Effects of Methanolic Extract of the bark of Khaya Senegalensis on Various Isolated Tissues Preparations

In this study the methanolic extract of the bark of Sudanese plant Khaya senegalensis was investigated for its effects on isolated rabbit jejunum, rat uterus, rabbit aortic strip, frog rectus abdominis and guinea pig atria. When methanolic extract of bark of Khaya senegalensis was added to isolated rabbit intestine it inhibited the spontaneous contracting rabbit jejunum and this activity was blocked by phentolamine, implicating -adrenergic stimulant activity, when added to isolated rat uterus it stimulated the rat uterus and this activity was blocked by cyproheptadine, implicating serotonin like activity. It had no effect on rabbit aortic strip, frog- rectus abdominis and guinea- pig atria.