Evaluation of Red Cell Transfusion Effects on Tissue Oxigenation, Based on Blood Lactate Levels As Sensitive Indicator of Tissue Oxygenation

Purpose Evaluation of red cell transfusion effects on tissue oxygenation, by measuring blood lactate levels before and and after hemotransfusion. Blood lactate level are suggested as sesitive parameter to evaluete tissue oxigenation. The aim of this stydy was to verify the efficiency of hemotransfusions that were performed on patients in intensiv care based on lactate level. Study design Prospective observational Methods In this prospective observational stydy on (n- 59 patients) who considered that required red cell transfusion. (the patients more that 25 point according to APACHE II-score were excluded). We monitor vital sings (BP, HR) at addmision and also was stictly observed lactate level and hemoglobin level at addmision before red cell transfusion (pre T), two hours after transfusion (2h post T) and 24 hours after (24 h post T with or no any another red cell transfusion). At first the patients group based at hemoglobin level, Group Ia with Hbless than 8g/dl and Group IIb with Hb - 8g/dl. After that the patients group again based at lactate level, Group Ic lactat level - 2, 4 and Group IId lactate level less than2, 4. Results Comparison between group Ia and group IIb as belongs hemoglobin level demonstrate significance only at addmision pre T and lost significance at 2h post T and 24h post T, at the other hand differences between group Ic and gropIId as belongs hemoglobin level stay significant at pre T, 2h post T and 24h post T Conclusions Statistical significant evaluation (p less than 0, 05) between above mentioned groups shown that lactate level are very sensitive indicator in measuration of tissue oxygenation. . Another important finding was significant high mortality and morbidity at patient group with lactate level - 2, 5.