Etiopathogenetic Cellular Mechanisms in Oral Lichen Planus

Objective to follow the immune status in patients with oral lichen planus (OLP), by assessing the level of T and B lymphocytes in the blood. Material and method 54 patients with OLP and 50 healthy people were examined. Experimental group was divided into three subgroups reticular, erythema-exudative and bullus form. Both groups, control and experimental, were assessed for values of T and B lymphocytes in the blood in the Institute for Transfusion. Findings were statistically processed using the Student-t test. Results In the phase of exacerbation in all three clinical forms of OLP, T and B cells in peripheral blood were increased, versus the control group (pless than0.001). In the phase of remission in reticular, erythema-exudative and bullous form, slight decrease in the values of T and B cells was observed, but it was still above control values and with high significance (pless than0.001), except for B lymphocytes in the reticular form where p less than0.01. Conclusion The increased values of T and B lymphocytes in the phase of exacerbation and remission, are explained with the chronicity of the process, which leads us to the conclusion that the immune system is reconstructed in terms of increased cell activity.