Evaluate the Effect of Coenzymeq10 Supplementation on Reducing Oxidative Stress in Patients with Relapsing Remitting Multiple Sclerosis

Multiple sclerosis its a disease cause demyelination of the central nervous system (CNS). its long duration result in individual, family tremendous & societal cost as well as reduction in life quality & work productivity. oxidative stress may play a key role in its pathogenesis. The aim of this study was to evaluate the effect of coenzyme Q10 (CoQ10) 200mg/day supplementation on oxidative stress and antioxidant enzyme activity in patients with relapsingremitting MS (RRMS). Materials and methods the study was a single-blind, randomized (placebo-controlled) study to determine the effect of CoQ10 supplement (200 mg/day, n=20) versus placebo (control, n = 20) for 24 weeks. Blood samples were taken before and after a 24-week intervention to analyze malondialdehyde (MDA) and the antioxidant enzyme superoxide dismutase (SOD) activity, liver and renal function (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AlkP), s. urea and s. creatinine) was measured to evaluate the safety of CoQ10. Results Forty subjects with RRMS completed intervention study. After 24 weeks, CoQ10-treated patients had significant increase in SOD activity (p = 0.000), and decrease in MDA levels (P=0.000) compared with placebo group. CoQ10 supplementation have no significant effect on EDSS, liver and renal function. Conclusion in the present study suggests that CoQ10 supplements at a dose of 200 mg/day for 24weeks is safe and can decrease oxidative stress and increase antioxidant enzyme activity in patients with RRMS.