Relationship between High Risk Human Papilloma Virus and Immune Expression of Mutated Retinoblastoma (Rb) Protein in Oral Cancer

Background The Retinoblastoma (Rb) is mutated in many types of cancer, since it can be expression even in advanced stages of the disease, HPV has been linked to etiology of oral cancer (OC). The abilities of high-risk HPV (HRHPV) E7 proteins to relationship with the pRB, has been suggested as a mechanism by which these viral proteins induce tumor. the aim of this study was to find out the relationship between mutated Rb protien and this virus. Methodology in this study 100 patients with (OC) were investigated retrospectively. Mutarted Rb was demonstrated by immunohistochemistry using mutated Rb antibody. HRHPV was identified by polymerase chain Reaction (PCR). Results Out of the 200 patients, 12/100 (12 %) were found with HR-HPV. Rb was identified in 25/100 (25 %) patients. Rb and HPV correlation was identified in 2/12 (17 %) with P value greater than0.05. Conclusion In OC, there is no significant correlation between mutated Rb protien and HRHPV