Plasma Uric Acid Levels in Patients with Diabetes Mellitus and Impaired Glucose Tolerance Test in Comparison with Normal Subjects

BACKGROUND Plasma uric acid has been shown to be associated with an increased risk of hypertension, cardiovascular disease,. chronic kidney disease, insulin resistance and metabolic syndrome. However the putative association between serum uric acid level and diabetes mellitus is not clear. This study aimed to investigate the plasma uric acid levels in patients with Type 2 DM and patients with IGT in comparison with normal subjects Methodology This is a case control study conducted in M. B. S. Hospital over a period of years2012-13. Serum uric acid and serum glucose concentration were measured in both control and patients groups (Group 1 patients of Type 2 DM, Group 2 patients with IGT and Group 3 normal subjects) Results Serum uric acid concentration was lower in diabetic group (3.320.882) as compared with control group (4.741.51) and was significant (pless than0.001). Serum uric acid concentration was higher in IGT group (6.191.13) when compared with control group (4.741.51) (pless than0.001) and was significant Conclusion Serum uric acid concentration is slightly reduced in patients with Type2 DM and this may be due to increased excretion of uric acid during hyperglycemia and glycosuria. Serum uric acid concentration is increased in patients with IGT and factors contributing to it are still unclear