Ameliorative Effect of Methanolic Extract of Cassiaoccidentalis (MECO) Whole Plant, on Triton X-100-Induced Hyperlipidaemia in Albino Rats

This study revealed the evaluation of phytochemicals and ameliorative effect of methanolic whole plant extract of Cassia occidantalis (MECO) on triton X-100-induced hyperlipidaemia in albino rats. Qualitative phytochemical analysis of MECO was conducted using standard methods. In hyperlipidemic model, the rats were divided into five groups, where hyperlipidaemia was induced to all groups with the exception of normal control group which received only normal saline instead. On completion of 14 days of treatment with MECO and Simvastatin (Standard drug) on the hyperlipidemic rats, blood was collected through cardiac puncture for estimation of serum lipid profile with subsequent cervical dislocation of the rats. Qualitatively, MECO shows variety of phytochemicals including flavonoids, saponins, tannins, anthraquinones, cardenolides, and alkaloids. Upon administration of 250-2000 mg/kg body weight of the extracts for acute toxicity test, there was no any observable behaviour change and or mortality recorded. Both the two doses (200 and 400 mg/kg body weight) of MECO in the treatment of hyperlipidaemia show significant (pless than0.05) increased in serum high-density lipoprotein cholesterol (HDL-c) and decreased in total cholesterol (TC), triglycerides TG), very low-density lipoproteins (VLDL-c) as well as low-density lipoproteins (LDL-c) in test groups as compared to untreated hyperlipidemic groups. It can therefore, be concluded that MECO whole plant maintain lipid homeostasis by restoring the abnormal level of serum lipid profile back to normal and thereby minimizing the risk of coronary heart diseases and their associates in hyperlipidemic albino rats.