Invitro Studies on Antidiabetic Effect of Aegle Marmelos Plant Aqueous Extract

Diabetes has become a major metabolic disorder disease that is increasingly becoming a killer disease worldwide. The aim of this study was to evaluate (bael tree) Aegle marmelos plant extract has the potential efficiency to manage diabetes mellitus type 2, that affects kidney and liver, in streptozotocin induced rats. Wister strain male rats were used grouped into three groups. The first group was used as control, the second group was induced diabetes by inducting streptozotocin 70mg/kg, the third group was induced diabetes and treated with A. marmelos aqueous plant leaves extract in the increasing dosage of 250mg/kg, 350mg/kg and 450mg/kg body weight from the 3rd to 21st day. Induction of streptozotocin affected the liver, kidney and their histopathology. Biochemical tests and histopathological studies were conducted. After administration of Aegle marmelos extract in increasing level, glucose level was significantly less than 0.05. h Kidney and liver parameters creatinine, urea, cholesterol protein, alanine transaminase (ALT), aspartate transaminase (ALT), alanine phosphate (ALP), albumin were also significantly pless than 0.05 reduced from 16th day of study. Histopathalogical results showed reduced inflammatory cellular lining in liver for the rats that were treated with the aqueous plant extract after inducing diabetes, while the histopathological test for pancreas showed reduced focal damage for the animals that were treated with the plant extract after inducing diabetes. From this results we found that Aegles Marmelos plant has therapeutic effect as renoprotective, hepatoprotective, and hypoglycaemic.