Attenuation of Cadiovascular Responses to Laryngoscopy and intubation: A Comparative Study between IV Esmolol Hydrochloride and Fentanyl Citrate

Objectives To study the effects of Esmolol (2mg/kg IV) bolus and Fentanyl (2mcg/kg IV) bolus given 3 minute before laryngoscopy and intubation in attenuating the sympathetic stress response. Study designHundred adults (1860 yrs), ASA grade I and II, of either sex undergoing elective surgical procedures under general anesthesia were included in this comparative study. Subjects were divided into two groups of 50 each. Group E receive Esmolol 2mg/kg IV bolus and Group F receive Fentanyl 2mcg/kg IV bolus 3 minute prior to laryngoscopy and intubation. Pulse rate, Systolic and Diastolic blood pressures, mean arterial pressure were recorded at following stages Baseline values 3 minute prior to laryngoscopy and intubation, After giving study drug, On laryngoscopy and intubation, 1 min after intubation, 2min after intubation, 3min after intubation, 4min after intubation, 5min after intubation and finally at 10minute after intubation. Results Pulse rate, Systolic BP, Rate pressure product was significantly attenuated by esmolol. Esmolol has very liitel effect on mean arterial pressure and has no effect on diastolic pressure. Conclusion Intravenous esmolol 2 mg/kg is more effective in the attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation than intravenous fentanyl 2mcg/kg.