Comparative Study of the Intravenously Administered Dexmedetomidine and Clonidine on Attenuation of Haemodynamic Responses to Pneumoperitoneum during Laparoscopic Cholecystectomy

Background: Now a day?s laparoscopy has become the standard technique for cholecystectomy over open surgery because of reduced postoperative pain and instabilities.Clonidine and dexmedetomidine both are alpha 2 adrenoreceptor agonist, but as compare to clonidine dexmedetomidine is more selective. This study compares the effect of intravenously administered clonidine and dexmedetomidine in attenuating the haemodynamic responses to pneumoperitoneum during laproscopic cholecystectomy. Methodology: 60 adult consented patients of ASA physical status I and II, aged between 18 to 60 years, of either sex scheduled for elective laparoscopic cholecystectomy were randomized into 2 groups (Group C, D) in a double-blind fashion, to receive either clonidine 1 ?g/kg or dexmedetomidine 1 ?g/kg both diluted with normal saline to make total volume 50 ml and administered over a period of 15 minutes before induction. Result: Group D showed better control in attenuation of increase heart rate and blood pressure due to pneumoperitoneum creation than Group C. Conclusion: Both clonidine and dexmedetomidine attenuate thehaemodynamic responses to pneumoperitoneum but dexmedetomidine showed better attenuation.