Formulation Development and Invitro Evaluation of Rosuvastatin Porous Tablets by Using Sublimating TechniqueJournal: International Journal of Science and Research (IJSR) (Vol.10, No. 8)
Publication Date: 2021-08-05
Authors : Asim Mohammed;
Page : 504-508
Keywords : stability studies; Weight variation; subliming agents; Camphor;
Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl- coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG- CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.This dissertation work was done with an aim to design an immediate release oral dosage of Rosuvastatin and evaluation of the tablets for various parameters including in vitro drug release studies. Rosuvastatin tablets were formulated by using microcrystalline cellulose and lactose monohydrate as fillers, camphor and menthol as subliming agents, crospovidone and CCS as super disintegrant and magnesium stearate as lubricant. The powdered blend were compressed into tablets and were analyzed for the parameters such as average weight, disintegration time, friability, thickness, weight variation, hardness, moisture content and drug content. The formulation F6 containing 10% of camphor showed disintegration time of less than 30seconds after drying.
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