1, 10 - Phenanthroline as Reagent for the Spectrophotometric Determination of Nanoamounts of Certain Antiulcer Drugs in Pharmaceutical Formulations

Simple, sensitive and accurate spectrophotometric method for the determination of certain benzimidazole class of antiulcer drugs has been developed. The method is based on the reaction of omeprazole (OMZ), lansoprazole (LNZ), pantoprazole (PNZ), rabeprazole (RBZ) and esomeprazole (EMZ) with iron (III) and subsequent complexation with 1, 10 - phenanthroline which yields a orange coloured product with maximum absorption at 510 nm. The commonly encountered excipients and additives along with the drug did not interfere with the determination. Antiulcer drugs in the range of 200 - 4000 ng ml - 1 for LNZ, PNZ and RBZ, 80 - 2800 ng ml - 1 for OMZ and 200 - 3800 ng ml - 1 for EMZ can be determined by this method. Results of the analysis of commercial capsules/tablets (omelac capsule, lanpro capsule, pan tablet, rabeloc tablet and raciper tablet for OMZ, LNZ, PNZ, RBZ and EMZ, respectively) by this procedure agree well with those of the reported method.