Elevated Monocyte Serum Levels as a Risk Factor for Preterm Labor

Preterm delivery is still an obstetric problem today, because it often causes perinatal morbidity and mortality. Monocytes are non - specific inflammatory cells that respond early to inflammatory reactions, especially in the endometrium, so logically, the levels will be high both in the cervix and in the mother's serum. This study aims to determine that high levels of maternal serum monocytes are a risk factor for preterm labor. This research uses a case control study. Samples were taken on cases that met the inclusion and exclusion criteria, and were divided into two groups. This research was conducted at the Obstetrics - Gynecology Polyclinic and in the Emergency Room of the Sanglah Hospital Denpasar. The time of the research was carried out from 22 June 2020 to 31 October 2020. Based on the distribution of the sample in this study, it can be concluded that the majority (86.4%) were in the 20?35 - year age group and the proportion in thegreater than 35 years and less than20 4.5% and 9.1% respectively. The Fisher's Exact Test statistical test was carried out, it was found that p = 0.664 was not significantly different between the age of the mother and the incidence of preterm labor. From this study, it was found that high levels of maternal serum monocytes had a statistically significant relationship with the incidence of preterm labor (p = 0.016, OR 5.714, 95% CI 1.560 - 20.929).