Spectrophotometric Method for Analysis of ValasartanJournal: International Journal of Science and Research (IJSR) (Vol.10, No. 11)
Publication Date: 2021-11-05
Authors : K. Sandhyarani;
Page : 660-662
Keywords : Beer's Law; Cobalt thiocyanate; Extractive Spectrophotometry; Nitrobenzene; Valsartan;
A simple, sensitive and cost effective visible spectrophotometric method has been developed for the determination of Valsartan from bulk and tablet dosage forms. The method is based on the formation of green colored coordination complex by the drug with cobalt thiocyanate which is quantitatively extractable into nitro benzene with an absorption maximum of 605nm. The Regression analysis of Beer?s Law plot showed good correlation in a general concentration range of 0.5 ? 3.0 ml, 400?g/ml with correlation coefficient (r= 0.992). The proposed method is validated with respect to accuracy, precision, linearity and limit of detection. The suggested procedure is successfully applied to the determination of the drug in pharmaceutical preparation, with high percentage of recovery, good accuracy and precision. The results of analysis have been validated statistically by repeatability and recovery studies. The results are found satisfactory and reproducible. The method is applied successfully for the estimation Valsartan in tablet form without the interference of excipients.
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