Design and Development of Quercetin Loaded Silver Nanoparticles for Antibacterial ActivityJournal: International Journal of Science and Research (IJSR) (Vol.10, No. 12)
Publication Date: 2021-12-05
Authors : Ritu Sharma; Dinesh Kaushik; Devender Chauhan;
Page : 1301-1309
Keywords : Silver nanoparticles; Quercetin; Antibacterial Activity; Trisodium citrate;
Nanotechnology has gained huge attention over time. It be spherical, cylindrical, tubular, conical, hollow core, spiral, flat, etc. or irregular and differ from 1 nm to 100 nm in size. . Biodegradable polymeric nanoparticles, particularly those coated with hydrophilic polymer such as poly(ethylene glycol) (PEG) known as long-circulating particles, have been used as potential drug delivery devices because of their ability to circulate for a prolonged period time target a particular organ. Quercetin (Qu) is one of the major bio flavonoid and forms the backbone of many other flavonoids. Materials: Quercetin (Konark Herbal & Health Care Pvt. Ltd., HP), Silver nitrate (Thermo Fisher Scientific Pvt. Ltd., Mumbai ), Tri sodium citrate (Nice chemicals Pvt. Ltd., Mumbai, India ), Methanol (LOBA CHEMIE Pvt. Ltd., Mumbai). silver nanoparticle containing quercetin is an attempt to utilize the potential of Ag NPs as a carrier to increase the activity of quercetin. So, we developed and evaluate the Ag NPs containing quercetin to obtain the optimized formulation with increased antibacterial activity. Discussion: Formulate and evaluate silver NPs containing quercetin for drug delivery in resistant microbial strains. In-vitro evaluation of silver NP formulation for the release characteristics of drug. Determination of antibacterial activity of silver NP containing quercetin. Conclusion: Quercetin is used in the treatment of infection caused by Escherichia coli, Streptococcus aureus, Pseudomonas aeruginosa, Helibacter pylori, other gram negative and gram positive bacteria. Ag NPs formulation of quercetin alters the chemical structure of quercetin and it becomes active against resistant bacteria. The Ag NPs containing quercetin were prepared by chemical reduction method and evaluated. Based on R2 value the formulation followed First order model.
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