The Relationship between Age, BMI, Insulin Resistance and ? Cell Function in Chinese Population

Introduction: Almost all related studies investigating the relative effects of insulin resistance and ? cell function on fasting blood glucose in the past have faced two major disability factors: age and body mass index (BMI). The application of Homeostasis Model Assessment (HOMA) equation in daily routine faces more and more frequent to both aging and obesity problem. The current study, we want to shed light on the two main factors associated with HOMA equation. Methods: A total of 866 subjects were eligible for further analysis. Homeostasis Model Assessment-Insulin Resistance index (HOMA-IR) and Homeostasis Model Assessment ?-cell function index (HOMA-?) were also calculated. Results: HOMA-IR was correlated only with BMI but not age. HOMA-? significantly correlated with both BMI and age. HOMA-IR was independently correlated with SBP, DBP, and TG only, other factors were washout after adjustment by either BMI only or both BMI and age. Only TG was independently correlated with HOMA-? after both BMI and age adjustment. Conclusion: Both insulin resistance and ?-cell function were independently related to the body mass index. However, age seems related to insulin resistance but nor ?-cell secretion. Larger sale analysis may be needed for further exploration of the underlying mechanism.