FORMULATION AND EVALUATION OF CEFADROXIL GASTRO RETENTIVE DRUG DELIVERY SYSTEMS

The aim of the Present study is to formulate and evaluate Antibiotic Cefadroxil as gastro retentive drug delivery system in raft formulation using sodium alginate as the polymer. Formulations were designed using different grades of Eudragit polymers. Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in gram-positive and gram-negative bacterial infections. It is a bactericidal antibiotic, cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or streptococcal tonsillitis, urinary tract infection, reproductive tract infection, and skin infections. Considering the wide range of activity of Cefadroxil, the objective of this study was to decrease the dose frequency and increase the speed of recovery from the indications by increasing the rate of bacterial killing and thereby increasing patient compliance. The formulations were designed using eudragits of different grades in different concentration ratios individually and in combination. All the formulations were evaluated for their Preformulation and Post formulation studies. The formulations were optimized and the best formulation was selected by the invitro drug release studies. The optimized formulation was found to sustain the drug for maximum time and is found to be stable. Keywords: Cefadroxil, Gastro retentive, Sodium alginate, Eudragits.