To Study the Role of P53 and KI-67 in Differentiating Benign and Malignant Prostatic Lesions: A Study of 81 Cases at LLRM Medical College, Meerut

Introduction: Immunohistochemistry can play an important rolein diagnostic surgical pathology and prognosis of prostatic lesions. Role of IHC markers p63, CKbE12 is well established and p53 and KI-67 are bring evaluated for their role as predictive or prognostic markers. Aims and objectives: To evaluate the immune-expression of p53 and ki-67 in benign and malignant prostatic lesions and their clinicopathological correlation. Material and methods: This study was done in LLRM Medical College attached to SVBP hospital Meerut, which included 81 patients with their detailed demographic data and clinical features of patients were studied with cystoscopic findings, serum Prostate specific antigen levels, histopathology and immunohistochemistry. Results: In our study, maximum cases were benign 52cases (64.2%), around 11cases (23.5%) were pre malignant and 18 cases (22.2%) were malignant. Stronger immune-positivity for p53 and Ki-67 was seen in higher grade of prostate cancer. Most common Gleason grade 2 (score 3+4) was seen in 08 cases (44.5%).