Outcome Comparison Fresh versus Frozen Embryo Transfers in Bali Royal Hospital

Background: The aim of this retrospective cohort study was to compare the outcome for the ?electively freeze-all? strategy and those destined for the ?fresh-transfer? strategy preceding subsequent FET. Methods: This retrospective single-center study analyzed the cumulative live birth rates (CLBRs) of 159 patients undergoing fresh or electively frozen blastocyst transfer cycles. In 81, cycles, the fresh embryo transfer (ET) strategy was applied for the 1st ET, whereas electively frozen ET (e-FET) was performed in other 78 cycles. The patients in each arm were further stratified into four subgroups according to the number of oocytes retrieved as follows: Group A: 1?5, group B: 6?10, group C: 11?15 and group D: 16?25 oocytes retrieved. The primary endpoint was the CLBR. The secondary endpoints were the live birth rates (LBRs), outcome in pregnancy such as IntraUterus Fetal Death, abortus, and hyperstimulation. Results: The CLBRs were similar between the fresh-transfer and e-FET arms in group 1?5 oocytes retrieved (2/7 [28.6%] vs 4/11 [36, 4%], p = 0.722), group 11?15 oocytes retrieved (6/12 [50%] vs 7/14 [50%], p=0, 440) and group 16?25 oocytes retrieved (8/13 [61, 5%] vs 6/9 [66, 7%], p=0, 362). However, in group 6?10 oocytes retrieved there is significant difference between two group (11/18 [61, 1%] vs 7/16 [43, 7%], p = 0.049). The perinatal outcome of Intra Uterine Fetal Death, abortus, and overstimulation were shown to be not significantly different between fresh ET and e-FET group. Conclusion: Compared to the fresh transfer strategy, the e-FET strategy resulted in higher CLBR among patients and the number of 6-10 oocytes collected during the cycle resulted in a better CLBR in the e-FET compared to fresh.