A Review on TNBS Model: Chemical and Procedure

TNBS model is the method to induce the ulcerative colitis in the rat. This method helps to analyse the disease condition in humans because the pharmacology and anatomy of GIT in humans and rats is somewhat similar. This model helps to determine the disease severity and medicine used to treat the disease.2, 4, 6-trinitrobenzene sulfonic acid (TNBS), is the TNBS solution that induces colitis in rats. In this article we study the instruments, chemical reagent, and procedure for TNBS induced colitis.