An Observational Study to Assess Hormone Receptor Status and its Correlation with Age at Diagnosis, Tumor Size, Histological Grade and Lymph Node Metastasis in Breast Cancer

Introduction: The breast has always been the symbol of womanhood and feminity. Breast cancer is the most common female cancer worldwide representing early a quarter (25%) of all cancers with an estimated 1.67 million new cancer cases diagnosed in 2012. After lung cancer, breast cancer is the second leading cause of cancer-related death in women. Aim and Objective: To assess hormone receptor status and its correlation with age at diagnosis, tumor size, histological grade and lymph node Metastasis in Breast Cancer. Material and Methods: This was a Hospital based validational type of observational study conducted during May 2020 to JAN 2022 or till sample size is reached, whichever is earlier at Department of Oncosurgery and General Surgery, SMS Hospital Jaipur. The study included the sample size to be 55 subjects at alfa error 0.05 and study power 80% assuming a proportion of lymph node involved by ER/PR status as ER+/PR+, ER+/PR-, ER-/PR+, ER-/PR-TO BE 53, 94.1, 94.1, 58.4, respectively hence for the study purpose 60 subject will be taken, who went through inclusion and exclusion criteria are included in this study. Result: In this study we analysed Sample size at 55 subjects at alfa error 0.05 and study power 80% assuming a proportion of lymph node involved by ER/PR status as ER+/PR+, ER+/PR-, ER-/PR+, ER-/PR-TO BE 53, 94.1, 94.1, 58.4, respectively hence for the study purpose 60 subject will be taken. Maximum numbers of patients are (45 out of 115) from 41-50 years of Age group. We compared Hormonal receptor status with age at diagnosis, we found that younger patient were less likely to be ER/PR positive as compared to older patients. In less than 40 years old cases 33.3% are ER/PR positive and 56.67% ER/PR negative compared to greater than 50 years old in which 75.0% cases are ER/PR positive and 17.50% ER/PR negative. Conclusion: The study shows that in palpable lesion the sensitivity and accuracy of CNB is more than FNAC and CNB provide additional information to correctly diagnosis nearly all cancer. Maximum numbers were in the age group of41-50 years. The left sided breast is more commonly involved (60.0%) than right (40.0%) in our study. The upper outer quadrant was most. Commonly involved (69.5%). We compared ER/PR positivity with age at diagnosis and found that younger patient were less likely to be ER/PR positive as compared to older patients.