Study of Clinical Profile and Liver Function in COVID-19 Patients at Tertiary Care Center: A Retrospective Study

Background: Although COVID-19 primarily affects the lungs, about 60% of patients also have varying levels of liver injuries or liver dysfunction in various studies Materials and Methods: This is a retrospective single-center study in patients admitted to the COVID ICU and COVID Ward of Dr. DY Patil Hospital, Nerul, Navi Mumbai. 300 patients with confirmed real-time polymerase chain reaction status for COVID-19 admitted and treated from June 1st, 2021 to August 1st, 2021 were included in this study. Results: Out of 300 patients that were enrolled in the study, 182 (60.67%) patients were males whereas 118 (39.33%) patients were females, and the mean age of patients was 56.09 ? 16.604 years. Out of all the patients, 142 (47.33%) had mild to moderate disease whereas 158 patients (52.66%) had severe disease. The liver function test revealed mean total bilirubin of 0.85?0.68 mg/dl, SGOT mean value was 77.42?99.48 IU/l and for SGPT it was found to be 67.27?85.4 IU/l and ALP was 120.59?65.95 IU/l. The mean albumin level was 3.4? 4.6 g/dl. Abnormal liver function tests were observed in 45.33% of cases. Abnormal total bilirubin, SGOT, SGPT, and ALP were seen in 10.6%, 45.33%, 68.38%, and 3.33% cases, respectively. It was found that there was a positive correlation between LFT (Total Bilirubin, AST, ALT, Albumin) and severity. Conclusion: The majority of the patients with COVID-19 infection presenting to our hospital were severe. Breathlessness, fever, and cough were the most common symptoms. Abnormal LFTs are high in COVID?19 patients and abnormality correlates with the severity of the disease.