Tumor Budding in Oral Cavity Cancer | Biomedgrid

Tongue squamous cell carcinoma (TSCC) is the most common carcinoma in the oral cavity with a tendency to rapid invasion and local spread and high recurrence rate. The detection of TSCC at an early stage (T1/T2N0M0) does not always predict a good prognosis. Therefore, it is important to identify prognostic markers that can be evaluated in biopsies. Tumor budding (TB) histologically represent the epithelial mesenchymal transition (EMT) and specifically in TSCC, TB correlates with hidden lymph node metastases and lymph node metastases and poor prognosis. The objetive of this review is to summarize the evidence supporting the implementation of TB in the TSCC as a predictive biological marker of poor prognosis.