Okra (Abelmoschus esculentus L. Moench) as Anti-cholesterol, Anti-diabetic and Anti-obesity in White Male Rats

Hypercholesterolemia is cholesterol elevation condition in blood serum. Type 2 Diabetes Mellitus is a metabolic disorder increasing significantly around the world, associated with obesity and lipid accumulation in the body. Okra (Abelmoschus esculentus L. Moench) is used as anti-obesity and anti-cholesterol empirically. The objective of the study was to determine the anti-obesity, anti-diabetic and anti-cholesterol activity of okra ethanolic extract in animal high-fat diet model. We conduct short- and long-term anti-obesity, anti-diabetic and anti-cholesterol test. The blood sample was collected from all rats after 8 hours fasting previously. Short- (p = 0.000) and long-term test (p = 0.005) showed significantly different parameter between the negative and positive group. Dose III showed no significant differences compared to positive group (p > 0.05) in the short-term test while, Dose I, II and III showed no significant differences compared to positive group in decreasing cholesterol level in the long-term test, Dose III showed the best activity in decreasing cholesterol level in blood serum and was equivalent with the positive group.