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Analysis and detection of incident light attenuation with a continuous flow injection by using the precipitating reaction of fluconazole and phosphomolybidic acid by NAG4SX3-3D instrument

Journal: Asian Journal of Green Chemistry (Vol.6, No. 3)

Publication Date:

Authors : ; ;

Page : 255-272

Keywords : Fluconazole; Turbidity; continuous flow injection analysis; Attenuation of incident light;

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A quick and sensitive approach for detecting fluconazole by formation a pale yellow precipitate from the interaction of phosphomolybdic acid and fluconazole in a sulfuric acid medium. The relevant parameter was investigated to increase the sensitivity of the newly proposed technique. L.O.D. = 16.0792 ng/sample at the lowest concentration on the calibration curve over the progressive dilution exhibited, a linear range (0.01-6) mmol.L-1 for fluconazole measurement, significantly lower than 0.2 RSD% for repetition (n = 6). With a linear R2 of 99.73% and a linear dynamic range of 0.9987, (correlation coefficient). The UV-spectrophotometric at λmax = 260 nm and the turbidimetric method were used as benchmarks against which to evaluate the performance of the suggested strategy. It was determined that, in comparison to the conventional method by using 10 mm irradiation, the sensitivity of the created technique, its usage of few chemicals, and its dynamic mechanism for preventing precipitated particle setting during tests all set it apart. The continual dilution of CFIA also allows for the manipulation of either high or low concentrations, thereby increasing the range of conceivable uses. Compared with the reference procedures, the developed method is thought to be the most accurate means of identifying fluconazole molecules in their purest and the most pharmaceutically effective forms.

Last modified: 2022-10-10 17:22:34