A STUDY OF CORRELATION BETWEEN THYROID FUNCTION TEST ABNORMALITIES AND TYPES OF VITILIGO

Background: Vitiligo is a chronic depigmenting disorder of skin and mucosal membrane which can be associated with many autoimmune cutaneous as well as systemic disorders. Association of vitiligo with various thyroid disorders has been implicated in various studies. Objectives: To evaluate the correlation of thyroid function test abnormalities in various types of vitiligo. Method: This is a case control study in which 82 cases of vitiligo and same number of age group and gender matched controls were enrolled. All patients including cases and controls were subjected to thyroid function tests (T3, T4, TSH), thyroid peroxidase (TPO) antibody test. The results were analyzed using chi square test. Results: Vitiligo cases had M:F ratio of 1:1.93, with the most commonly affected age group was 21-30 years consisting of 51.21% of total cases. The most common subtype of vitiligo was vitiligo vulgaris in 37.80% cases followed by Focal vitiligo in 28.04 % cases. The least common type was Lip-tip vitiligo seen in 2.44% cases. 31.70% cases and 2.44 % controls had TFT abnormalities. On interpretation the most common thyroid disorder found both in cases and controls was subclinical hypothyroidism. Conclusion: Thyroid abnormality is significantly associated with cases of Vitiligo than control. All the patients of diagnosed as vitiligo should undergo TFT and thyroid antibody evaluation on baseline and periodically.