Synthesis and Characterization of Novel Benzimidazole Derivatives and Evaluation of Their Anti Bacterial Activities

Background: The Benzimidazole scaffold is a useful moiety for the development of molecules of pharmaceutical or biological interest. Appropriately substituted benzimidazole derivatives have found diverse therapeutic applications. Methods: In the present work, the novel benzimidazole derivatives was synthesized and evaluated for their antibacterial activity. The newly synthesized compound were subjected to antibacterial activity against Bacterial strains such as gram-positive (S. aureus and B. subtilis) and gram-negative (E.coli& Proteus vulgaris). The concentration of the newly synthesized compounds 6a-f used for the anti-bacterial screening was 1000μg. The standard drugs used in the antibacterial screening were ciprofloxacin and amoxicillin (10 μg/ml).The structure of the synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR and Mass spectral analysis Results: In general, most of the compounds showed significant antibacterial activity but some compounds are more specific to particular strains of bacteria