ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Synthesis and Characterization of Novel Benzimidazole Derivatives and Evaluation of Their Anti Bacterial Activities

Journal: International Journal of Pharmaceutical Sciences Letters (Vol.3, No. 1)

Publication Date:

Authors : ;

Page : 173-176

Keywords : Benzimidazole; Anti bacterial; Amoxicillin; Ciprofloxacin;

Source : Downloadexternal Find it from : Google Scholarexternal


Background: The Benzimidazole scaffold is a useful moiety for the development of molecules of pharmaceutical or biological interest. Appropriately substituted benzimidazole derivatives have found diverse therapeutic applications. Methods: In the present work, the novel benzimidazole derivatives was synthesized and evaluated for their antibacterial activity. The newly synthesized compound were subjected to antibacterial activity against Bacterial strains such as gram-positive (S. aureus and B. subtilis) and gram-negative (E.coli& Proteus vulgaris). The concentration of the newly synthesized compounds 6a-f used for the anti-bacterial screening was 1000μg. The standard drugs used in the antibacterial screening were ciprofloxacin and amoxicillin (10 μg/ml).The structure of the synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR and Mass spectral analysis Results: In general, most of the compounds showed significant antibacterial activity but some compounds are more specific to particular strains of bacteria

Last modified: 2013-06-03 18:14:43