Hepatoprotective Effect of Methanolic Leaf Extract of Prosopis Cineraria on Paracetamol Induced Hepatotoxicity in Swiss Albino Mice

Aim: To evaluate the protective effect of methanolic leaf extract of Prosopis Cineraria on paracetamol-induced hepatotoxicity in mice. Materials and Methods: 30 Swiss albino mice of eithersex mice were used in this study and divided into 5 groups (for each 6). Group 1 Control group fed basal diet and maintained as positive control group. Group 2 received Paracetamol in a dose of (3 g/kg b. wt.). Group 3 received Paracetamolalong with Standard Drug (Silymarin) in a dose of (100 mg/kg). Groups 4 and 5 were treated with Paracetamol along with plant extracts of Prosopis Cineraria at a dose level of 250 g/kg and 500 mg/kg. Results:The activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), bilirubin, and total protein were measured. The values of urea, sodium, potassium and chloride were significantly increased in rats exposed to paracetamol. Moreover, administration of paracetamol resulted in damage to liver structures. Administration of methanolic extract of Prosopis Cineraria before Paracetamol exposure prevented severe alterations of biochemical parameters and disruptions of liver structures. Conclusions: This study obviously demonstrated that pre-treatment with methanolic extract of Prosopis Cinerariasignificantly attenuated the physiological and histopathological alterations induced by paracetamol.