Optimizing Vitamin D Status Improves Outcomes in Critical Ill and Injured Patients |Biomedgrid

In 2008, Giovanucci et al. [1] showed that men with low vitamin D levels suffered 2.42 times more myocardial infarctions than those with normal vitamin D status [1]. Alternatively, a sufficient amount of serum 25-hydroxyvitamin D3, [25(OH)D], appears to improve the risk of almost every disease of aging. Dobnig et al. [2] similarly demonstrated people with an inadequate vitamin D status have twice the likelihood of death over seven years [2,3]. Vitamin D sufficiency, define as serum 25(OH)D levels of 30ng/ mL (75nmol/L) and above, improves various health outcomes, including bone mineral density, fractures, and colorectal cancer, based on analysis of observational studies [4]. Vitamin D levels of 21-29ng/mL delineates insufficiency and a concentration of 20ng/ mL or less defines vitamin D deficiency [4].