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A Comparative Study on Global Genetic Diversity and Population Genetic Analysis of Orf Virus Isolates from Outbreaks and it’s Implications for the Vaccine Development |Biomedgrid
Journal: American Journal of Biomedical Science & Research (Vol.8, No. 4)Publication Date: 2020-04-08
Authors : Saeed Nazeri; Sajad Pezeshki Najafabadi; Homayoon Mahravani; Elaheh Aali; Arezou Karimpour; Mahdiyeh Sarmadi; Mehdi Hasanvand; Mohamad Hasanvand; Leila Hoseini;
Page : 235-245
Keywords : Contagious Ecthyma; Orf Virus; B2l Gene; Genetic Diversity; Population Genetic;
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Abstract
Introduction: Orf virus envelope gene (B2L) encodes a highly immunogenic protein that exhibits lipase activity. Since Orf virus strains change genetically, it is essential to have adequate information on geospatial genetic diversity of global B2L to design an appropriate contagious ecthyma vaccine.
Materials and Methods: For this purpose, we have investigated twenty-four Iranian Orf virus B2L genes that were recovered from tow outbreaks of contagious ecthyma in sheep and goats from four provinces of Iran and compared with related available global sequences in GenBank.
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