Molecular Analysis of The Rs1800629 Polymorphic Variant in the TNF-Gene in The Pathogenesis of Fetal Loss Syndrome |Biomedgrid

This paper presents molecular genetic research of the TNF- gene polymorphism in pregnant women with fetal loss syndrome. Analysis of molecular genetic research showed that allele A and heterozygous genotypes of the rs1800629 polymorphism in the TNF- gene may be markers of a tendency for an increased risk of developing fetal loss syndrome in Uzbekistan. There is a tendency towards an increase in the frequency of the unfavorable allele A of the TNF- gene in female patients with a severe form of Fetal Loss Syndrome (FLS) as compared with its mild case [1,2].