CORRELATIVE STUDY OF CORONARY ARTERY DISEASE SEVERITY AND GLYCOSYLATED HEMOGLOBIN IN DIABETIC AND NON-DIABETIC PATIENTS

Context: Diabetes mellitus and coronary heart disease are closely associated with each other and generally coexist. The severity of coronary artery disease is related directly to the quality of glucose control in diabetic patients Aims: To correlate coronary artery disease severity and glycosylated hemoglobin in diabetic and non-diabetic patients. Settings and Design:Study site: This study was conducted in the department of General Medicine at Sri Devaraj Urs Academy of Higher Education and Research, Kolar.Study design: The was a descriptive observational cross-sectional study. Methods and Material:Descriptive observational cross-sectional study conducted for a period of 1.5 years from January 2019 to June 2020. A total of 400 subjects were included in the final analysis. Statistical analysis used:Categorical outcomes were compared between study groups using Chi square test /Fishers Exact test .P value < 0.05 was considered statistically significant. IBM SPSS version 22 was used for statistical analysis.63 Results:The mean age of the participants was 57.97 ± 11.59. Majority of the participants were males with 82.25%. ST-elevation MI, non-ST elevation MI, unstable angina, and stable angina were the clinical presentation identified with 61.25%, 18.5%, 11.25% and 9% respectively. Troponin I was elevated in 80.5% of the participants. NSTEMI and STEMI were identified in 18.5% and 61.25% of the participants. The mean of LV Function in the study population was 47.32 ± 10.15. Among the study population, LMCA was identified in 9.25% whereas, Whereas, LCX and RCA in 52.25% and 65%. The mean of Hba1C in the study population was 7.47 ± 2.26. Conclusions: Increased HbA1c levels in the diabetes group was significantly associated with severity of CAD.