Evaluation of the effect of placental and spleen cryoextracts, and conditioned medium of mesenchymal stem cells, on thyroid hormone synthesis in experimental autoimmune thyroiditis

Background. Thyroid diseases (TD) are the most common endocrine disorders, affecting more than 10% of the adult population. The most prevalent forms of autoimmune thyroid diseases (AITD) are Graves disease and Hashimotos thyroiditis. The standard treatment for hypothyroidism involves restoring thyroid hormone levels to normalize their concentration in tissues. Our attention was drawn to the study of the efficacy of biotechnology drugs that do not contain cells subjected to low-temperature treatment during their production or prolonged storage.