Promising: Role of Steroids in Nasal Drug Delivery System

Since their discovery about 80 years ago, steroids have been extensively used in the treatment of wide range of disease states, namely asthma, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, and many others. Steroids are powerful anti - inflammatory and have immune modulating characteristics which play significant role in many clinical applications. Systemic steroids are an effective treatment for many skin disorders. Mucoadhesive microspheres serve as a way to enhance drug delivery by prolonging the duration of drug at the application or absorption site and facilitating close contact with underlying absorption surface. This helps to enhance and/or increase the therapeutic performance of drug. The process by which artificial and organic polymers attach to mucosal surfaces in the body is known as mucoadhesion. Drug absorption by mucosal cells may, in general, have the potency to be used for controlled and targeted release drug delivery if these materials are embedded into pharmaceutical formulations. However, coupling of mucoadhesive properties to microspheres has significant benefits like much more intimate contact with mucous layer, efficient absorption, and increased bioavailability of drugs due to high surface to volume ratio.