In-vitro Pharmacological Evaluation of Anti-diabetic Activity of Roots Extract of Doronicum Hookeri

In recent years, there has been a growing interest in exploring medicinal plants for their potential to yield more effective anti-diabetic drugs compared to conventional oral hypoglycemic medications. The current study focuses on Doronicum hookeri, a traditional medicinal plant, and investigated its in-vitro anti-diabetic properties through alpha-amylase inhibition assay, glucose uptake assay, and lipase inhibition assay. Among the various extracts, the methanolic roots extract of Doronicum hookeri exhibited the highest amylase inhibition with the lowest IC50 value (0.151). In contrast, the aqueous extracts from both plants demonstrated the most significant inhibition of glucose movement across the membrane, while the methanolic extract displayed the least inhibition. Additionally, the methanolic extract of Doronicum hookeri exhibited the strongest lipase inhibition with the lowest IC50 value (38.2). These findings suggest that Doronicum hookeri holds promise as a potential candidate for diabetes treatment.