Differences of Urinary Cartilage Type II Collagen C-Telopeptide (CTX-II) and Calcium Levels in Osteoarthritis Patients Based on Severity

Background: Osteoarthritis (OA) is a slow chronic disease characterized by the degradation of articular cartilage, causing joint space narrowing, loss of joint mobility and pain. Several studies have shown that urinary cartilage type II collagen C-Telopeptide (uCTX-II) is a promising biochemical marker in OA. OA is generally managed with palliative measures and symptomatic treatment, including calcium supplements. Calcium is the most abundant and second most abundant micronutrient that regulates neuromuscular function and skeletal mineralization of the body Objective: To determine the difference between Urinary Cartilage Type II Collagen CTelopeptide (uCTX-II) and Calcium levels in OA patients based on Severity. Methods: This research is an observational study with cross sectional data collection method. This study took blood samples from OA patients who were treated at the Polyclinic of the Department of Orthopedic Surgery and Traumatology Adam Malik General Hospital Medan. As many as 38 patients. Samples were checked for urine CTX II and Serum Calcium. The research was conducted after obtaining ethical approval and informed consent. Results and Discussion: This study was followed by 36 patients with OA. There were 30 female subjects (83.3%). The mean age of the subjects was 64.03 years with the youngest age being 42 years and age. Using the Anova test, it was found that there were significant differences in uCTX-II levels based on the severity of OA (p=0.043). Using the Kruskal Wallis test showed that there was no significant difference in calcium levels based on the severity of OA (p=0.944). Conclusions and suggestions: There was a significant difference in uCTX-II levels based on the severity of OA (p=0.043). On the other hand, Calcium was no significant differences based on the severity of OA (p> 0.005). Further research needs to be done with a larger sample size and associated using other markers such as Hyaluronic Acid.