DESIGN AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF ACE C LOFENAC BY SOLVENT EMULSIFICATION METHOD

The main objective of this investigation was to prepare and characterize different concen tration and different combination of rate retarding polymer ethylcellulose, Eudragit L100 and mucoadhesive polymer Carbopol 940 by solvent emulsification method to increase the residence time and controlled the drug release. The prepared microcapsules was found to be discrete, spherical and free flowing .The percent yield was found to be between 78.61% to 88.60% and encapsulation efficiency was found to be 90.78% to 97.84%. The microcapsules showed good mucoadhesive property in in vitro wash off test. The drug release was found to be followed first order release pattern and fit into Higuchi model. Hence the prepared mucoadhesives microcapsules was suitable to control the drug release and increase the residence time at target site specifically. Key Words: Ac eclofenac , mucoadhesive microcapsules, Higuchi model, emulsification method