Pharmaceutical Development and In Vitro Evaluation of Gastro Retentive Floating Tablets of Telmisartan

Gastro retentive drug delivery systems GRDDS have emerged as a promising approach to enhance the bioavailability of drugs exhibiting a narrow absorption window in the upper gastrointestinal tract. Telmisartan, an angiotensin II receptor antagonist with low aqueous solubility and variable oral bioavailability, is an ideal candidate for gastro retentive formulation. The present research focuses on the pharmaceutical development and in vitro evaluation of effervescent gastro retentive floating tablets of Telmisartan prepared by direct compression technique. Floating tablets were formulated using hydrophilic polymers and gas generating agents to achieve prolonged gastric residence time and sustained drug release. Pre compression and post compression parameters were evaluated to ensure acceptable flow, compressibility, mechanical strength, buoyancy, and drug content uniformity. In vitro buoyancy and dissolution studies demonstrated rapid floating lag time, prolonged floating duration, and controlled drug release up to 12 hours. The study confirms that gastro retentive floating tablets of Telmisartan can be successfully developed to enhance gastric retention and potentially improve bioavailability. Sweta Shakya | Mr. Ashvani Kumar "Pharmaceutical Development and In-Vitro Evaluation of Gastro-Retentive Floating Tablets of Telmisartan" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-9 | Issue-6 , December 2025, URL: https://www.ijtsrd.com/papers/ijtsrd99977.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/99977/pharmaceutical-development-and-invitro-evaluation-of-gastroretentive-floating-tablets-of-telmisartan/sweta-shakya