Sex-based Association of CYP11B2 (-344 C/T) Polymorphism in Indian Type 2 Diabetic Patients

Background: CYP11B2 gene association studies have been conducted on hypertension, T2DM, and T2DNH in subjects from Caucasian, Asian, and Indian populations. The -344 C/T variant is a commonly reported polymorphism of the CYP11B2 gene. The aim of the present study was to investigate the association between the CYP11B2 (-344 C/T) polymorphism and Sex in type 2 diabetic patients in the Indian population. Methods: The CYP11B2 (-344 C/T) polymorphism was identified by PCR-RFLP and sequencing. Results: The CYP11B2 gene CC, CT, and TT genotypes accounted for 14.55%, 50.00%, and 35.45% of the male T2DM subjects, 20.55%, 34.25%, and 45.21% of the male controls, 11.46%, 54.17%, and 34.38% of the female T2DM subjects and 11.11%, 44.44%, and 44.44% of the female controls. The CT heterozygote was more frequent among the T2DM subjects than among the controls. The C allele was most frequent among the male T2DM subjects (39.55%), followed by the female T2DM subjects (38.54%), the male controls (37.67%), and the female controls (33.33%). The T allele was most frequent among the male controls (62.33%), followed by the female controls (66.67%), the male T2DM subjects (60.45%), and the female T2DM subjects (61.46%). Overall, the distribution of CYP11B2 genotypes and allele frequencies did not differ significantly. Conclusion: We did not find any significant association of the CYP11B2 (-344 C/T) polymorphism with sex in the studied cohort.